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\/>\n\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u6e1b\u5c11\u3084\u8cea\u306e\u4f4e\u4e0b\u306f\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u539f\u56e0\u3068\u3057\u3066\u3082\u8003\u3048\u3089\u308c\u3066\u3044\u308b<br \/>\n\u591a\u7a2e\u985e\u3042\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u3046\u3061\u4eba\u306e\u4f53\u306b\u6700\u3082\u591a\u304f\u5b58\u5728\u3059\u308b\u2160\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u3001\u9aa8\u306e\u6709\u6a5f\u7269\u306e90\uff05\u4ee5\u4e0a\u3092\u5360\u3081\u3066\u3044\u308b\u3002<br \/>\n\u4ed6\u306b\u3082\u3001\u2160\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u3001\u8171\u3001\u976d\u5e2f\u306a\u3069\u591a\u304f\u306e\u7d50\u5408\u7d44\u7e54\u306b\u304a\u3051\u308b\u4e3b\u8981\u306a\u6210\u5206\u3067\u3042\u308b\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u7d44\u7e54\u306e\u4e2d\u3067\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u5404\u3005\u306e\u90e8\u4f4d\u306b\u304a\u3051\u308b\u5f37\u5ea6\u3084\u67d4\u8edf\u6027\u3092\u4fdd\u3064\u52b9\u80fd\u304c\u3042\u308b\u3002<\/p>\n<p>\u25cf\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u9aa8\u306e\u69cb\u9020\u306e\u30d9\u30fc\u30b9\uff08\u9aa8\u306f\u65e5\u672c\u5200\u306e\u3088\u3046\u306a\u69cb\u9020\uff09<\/p>\n<p>\u9aa8\u3068\u3044\u3046\u3068\u300c\u30ab\u30eb\u30b7\u30a6\u30e0\u3067\u3067\u304d\u3066\u3044\u308b\u300d\u3068\u30a4\u30e1\u30fc\u30b8\u304c\u3042\u308b\u304c\u3001\u5b9f\u969b\u306b\u306f\u300c\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u7e4a\u7dad\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u306a\u3069\u306e\u30df\u30cd\u30e9\u30eb\u5206\u304c\u4ed8\u7740\u3057\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u69cb\u9020\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n<p>\u30ab\u30eb\u30b7\u30a6\u30e0\u3060\u3051\u3060\u3068\u786c\u3044\u584a\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3068\u3053\u308d\u3092\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u304c\u3057\u306a\u3084\u304b\u306a\u30af\u30c3\u30b7\u30e7\u30f3\u6027\u3092\u9aa8\u306b\u4e0e\u3048\u308b\u3053\u3068\u3067\u5916\u90e8\u304b\u3089\u306e\u885d\u6483\u3092\u548c\u3089\u3052\u3001\u9aa8\u304c\u50b7\u3080\u306e\u304b\u3089\u5b88\u3063\u3066\u304f\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u9aa8\u306e\u5f37\u3055\u3092\u6e2c\u308b\u9aa8\u5bc6\u5ea6\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u306a\u3069\u306e\u30df\u30cd\u30e9\u30eb\u5206\u304c\u3069\u308c\u3060\u3051\u8a70\u307e\u3063\u3066\u3044\u308b\u304b\u3092\u78ba\u8a8d\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u304c\u3001\u300c\u9aa8\u5bc6\u5ea6\u306f\u5341\u5206\u3042\u308b\u306e\u306b\u3001\u9aa8\u6298\u306a\u3069\u306e\u30b1\u30ac\u3092\u3057\u3084\u3059\u3044\u300d\u3068\u3044\u3046\u65b9\u306e\u5834\u5408\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306f\u8db3\u308a\u3066\u3044\u308b\u3051\u3069\u30b3\u30e9\u30fc\u30b2\u30f3\u304c\u5c11\u306a\u3044\u305f\u3081\u306b\u9aa8\u304c\u3057\u306a\u3084\u304b\u3055\u3092\u5931\u3044\u3001\u5f31\u304f\u58ca\u308c\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n<p>\u4f53\u5185\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u3001\u6e1b\u5c11\u3057\u305f\u308a\u5e74\u9f62\u3092\u91cd\u306d\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u8cea\u304c\u4f4e\u4e0b\u3001\u9aa8\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u4ed8\u7740\u3057\u306b\u304f\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u306a\u3069\u652f\u969c\u3092\u304d\u305f\u3059\u304c\u3001\u539f\u56e0\u306f\u3001\uff08\u7b4b\u8089\u304c\u786c\u3044\u3053\u3068\u3082\u542b\u3081\u3066\uff09\u7cd6\u5316\u306b\u3088\u308b\u3053\u3068\u304c\u591a\u3044\u3002<\/p>\n<p>\u25cf\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u6e1b\u5c11\u3084\u8cea\u306e\u4f4e\u4e0b\u306f\u3001\u9ad8\u9f62\u8005\u306b\u591a\u3044\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u539f\u56e0\u3068\u3057\u3066\u3082\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u25cf\u6700\u8fd1\u306b\u306a\u3063\u3066\u3001\u98df\u4e8b\u306a\u3069\u3067\u4f53\u5185\u306b\u3068\u308a\u3053\u307e\u308c\u305f\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u9aa8\u3084\u95a2\u7bc0\u306a\u3069\u306e\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3001\u65b0\u305f\u306a\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u751f\u307f\u51fa\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u305f\u3002<\/p>\n<p>\u25cf\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u6975\u3081\u3066\u5206\u5b50\u91cf\u306e\u5927\u304d\u3044\u7269\u8cea\u306e\u305f\u3081\u3001\u305d\u306e\u307e\u307e\u3067\u306f\u5438\u53ce\u3055\u308c\u305a\u3001\u5206\u89e3\u3055\u308c\u30a2\u30df\u30ce\u9178\u3068\u306a\u3063\u3066\u521d\u3081\u3066\u5438\u53ce\u3055\u308c\u308b\u3002\u3067\u306f\u3069\u3046\u3057\u305f\u3089\u4f53\u5185\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5897\u3084\u305b\u308b\u306e\u304b\u3068\u3044\u3046\u3068\u3001\u305d\u306e\u6750\u6599\u3068\u306a\u308b\u3001\u305f\u3093\u767d\u8cea\u3001\u30d3\u30bf\u30df\u30f3C\u3001\u9244\u3092\u98df\u4e8b\u7b49\u3067\u3057\u3063\u304b\u308a\u6442\u308b\u3053\u3068\u3042\u308b\u3002<\/p>\n<p>\u25cf\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u75db\u3081\u308b\u7cd6\u5316\u53cd\u5fdc<\/p>\n<p>\u7cd6\u5316\u53cd\u5fdc\u306b\u3088\u3063\u3066\u7cd6\u5316\u6700\u7d42\u751f\u6210\u7269\u30fbAGEs\uff08\u30a8\u30a4\u30fb\u30b8\u30fc\u30fb\u30a4\u30fc\u30ba\/advanced glycation endproducts\uff09\u304c\u751f\u6210\u3059\u308b\u3002AGEs\u3068\u306f\u30011\u3064\u306e\u7269\u8cea\u306e\u540d\u79f0\u3067\u306f\u306a\u304f\u69d8\u3005\u306a\u7a2e\u985e\u306e\u5316\u5408\u7269\u306e\u7dcf\u79f0\u3067\u3042\u308b\u304c\u3001\u3053\u308c\u304c\u4e00\u65e6\u3067\u304d\u3066\u3057\u307e\u3046\u3068\u5143\u306b\u306f\u623b\u3089\u305a\u3001\u4f53\u306b\u84c4\u7a4d\u3055\u308c\u3066\u3044\u3063\u3066\u3001\u305d\u308c\u304c\u3055\u3089\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3057\u307e\u3046\u3053\u3068\u306b\u306a\u308b\u3002\u4f53\u5185\u306e\u7cd6\u5316\u3067\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u73fe\u8c61\u304c\u8d77\u304d\u3066\u3001\u5065\u5eb7\u9762\u3042\u308b\u3044\u306f\u7f8e\u5bb9\u9762\u3067\u3082\u69d8\u3005\u306a\u554f\u984c\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3057\u307e\u3046\u3002<\/p>\n<p>\u25cfAGEs\u306f\u7cd6\u306e\u5f71\u97ff\u3060\u3051\u3067\u306a\u304f\u3001\u98f2\u9152\u3084\u55ab\u7159\u3001\u8102\u8cea\u306e\u904e\u5270\u6442\u53d6\u3068\u3044\u3063\u305f\u69d8\u3005\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u751f\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u3002\uff08AGEs\u304c\u8001\u5316\u306e\u4e3b\u305f\u308b\u539f\u56e0\u3067\u3042\u308b\uff09<\/p>\n<p>\u25cf\u52d5\u8108\u786c\u5316\u306e\u539f\u56e0\uff1d\u7cd6\u5316<br \/>\n\u3044\u308f\u3086\u308b\u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u3042\u308bLDL-C\u306f\u3001\u901a\u5e38\u306a\u3089\u767d\u8840\u7403\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u98df\u3079\u3066\u5206\u89e3\u3057\u3001\u6d88\u3057\u3066\u304f\u308c\u308b\u3002\u3057\u304b\u3057\u3001LDL-C\u304c\u7cd6\u5316\u3057\u3066AGEs\u304c\u6e9c\u307e\u3063\u305f\u72b6\u614b\u306b\u306a\u308b\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u98df\u3079\u3066\u3082\u5206\u89e3\u3057\u304d\u308c\u305a\u306b\u201c<strong><span style=\"color: #ff0000;\">\u6ce1\u6cab\u7d30\u80de<\/span><\/strong>\u201d\u3068\u3044\u3046\u72b6\u614b\u306b\u306a\u3063\u3066\u8840\u7ba1\u306e\u5185\u58c1\u306b\u84c4\u7a4d\u3057\u307e\u3059\u3002\u3053\u308c\u304c<strong><span style=\"color: #ff0000;\">\u30a2\u30c6\u30ed\u30fc\u30e0<\/span><\/strong>\u3068\u3044\u3046\u7ca5\u72b6\u306e\u584a\u3092\u5f62\u6210\u3057\u3066\u52d5\u8108\u786c\u5316\u3092\u62db\u3044\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p>\u25cf\u7d44\u7e54\u306e\u708e\u75c7<br \/>\n\u7cd6\u5316\u306b\u3088\u3063\u3066\u3067\u304d\u3066\u3057\u307e\u3063\u305fAGEs\u306f\u3001\u84c4\u7a4d\u3059\u308b\u3070\u304b\u308a\u3067\u306a\u304f\u3001\u201cRAGE\uff08\u30ec\u30fc\u30b8\uff09\u201d\u3068\u547c\u3070\u308c\u308bAGEs\u306e\u53d7\u5bb9\u4f53\u3068\u7d50\u5408\u3057\u3001\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u7269\u8cea\uff08\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff09\u3092\u751f\u307f\u51fa\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d44\u7e54\u306f\u708e\u75c7\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u72b6\u614b\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3002<br \/>\n\u203bRAGE\u306f\u3001\u7d30\u80de\u306e\u8868\u9762\u304b\u3089\u3064\u304d\u3060\u3057\u3001\u7d30\u80de\u306e\u5916\u304b\u3089\u6765\u308b\u60c5\u5831\u3092\u53d7\u3051\u6b62\u3081\u308b\u3001\u53d7\u5bb9\u4f53\u3068\u3044\u308f\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u3064\u3067\u3059\u3002\u3044\u308f\u3070\u7d30\u80de\u306e\u30a2\u30f3\u30c6\u30ca\u306e\u3088\u3046\u306a\u50cd\u304d\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u306a\u3069\u3067\u4f53\u306e\u4e2d\u306b\u5897\u3048\u3066\u304f\u308bAGE (advanced glycation end-products, \u7d42\u672b\u7cd6\u5316\u7523\u7269)\u3068\u7d50\u5408\u3059\u308b\u53d7\u5bb9\u4f53\uff08receptor\uff09\u3068\u3057\u3066\u898b\u3064\u3051\u3089\u308c\u305f\u305f\u3081\u3001AGE\u306e\u53d7\u5bb9\u4f53 \u201dreceptor for AGE, (RAGE)\u201d 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href=\"https:\/\/biochem2.w3.kanazawa-u.ac.jp\/research.html\u3000\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002\">https:\/\/biochem2.w3.kanazawa-u.ac.jp\/research.html\u3000\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a>\n\t\t\t<\/p>\n<p>\u25cf\u3053\u306e\u4ed6\u306b\u3082\u3001\u9aa8\u3067\u7cd6\u5316\u304c\u8d77\u3053\u308c\u3070\u9aa8\u7c97\u9b06\u75c7\u3001\u8133\u3067\u306eAGEs\u84c4\u7a4d\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3082\u95a2\u4e0e\u3059\u308b\u306a\u3069\u3001\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u5168\u8eab\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u3084\u8001\u5316\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u304f\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u308b\u3002<\/p>\n<p>\u25cf\u4f53\u306e\u7cd6\u5316\u306f\u69d8\u3005\u306a\u75be\u60a3\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3002<br 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